what is anavar

When administered orally is well absorbed through the 0.8 hour half of the dose is absorbed; after 4.6 hours of half the dose is distributed in the body. After 1-2 hours after ingestion of a single dose of 250 mg of the maximum drug concentration in blood plasma reaches 0.97 g / ml. Bioavailability – about 40% (the effect of “first pass”). Food intake has no effect on the bioavailability of terbinafine.

Terbinafine binds extensively (99%) to plasma proteins, in tissues quickly spreads penetrates into the dermal layer of skin and nail plate. It penetrates the sebum and accumulates in high concentrations in the hair follicles in hair, skin and subcutaneous tissue.

.. The what is anavarhours,  of terminal phase – 200 -400 hours Biotransformiroetsa in the liver to inactive metabolites; 80% of the dose is eliminated via the kidneys as metabolites, the remainder (22%) – through the intestines. Not accumulates in the body. Age of the patients did not affect the pharmacokinetics of terbinafine, but elimination may be reduced in patients with lesions of the kidneys and liver, resulting in high concentrations of terbinafine in the blood. Provided with breast milk.

Indications

  • Fungal infections of the scalp (trihofitia, mikrosporiya);
  • Fungal infections of the skin and nails caused by Trichophyton (T.rubrum, T.mentagrophytes, T.verrucosum, T.violaceum), Microsporum (M. canis, M. gypseum) and Epidermophyton floccosum.
  • Onychomycosis.
  • Heavy, common ringworm smooth skin of the trunk and limbs requiring systemic treatment.
  • Candidiasis of skin and mucous membranes.

Contraindications
: Hypersensitivity to any component of the drug; Children up to age 3 years, pregnancy, lactation.

Precautions: Hepatic and / or renal failure, alcoholism, depression of bone marrow hematopoiesis, tumors, metabolic diseases, limb occlusive vascular disease.

Pregnancy and lactation: Reception terbinafine during pregnancy is contraindicated because of the lack of sufficient information about its safety during pregnancy. Terbinafine is excreted in breast milk, so his appointment is contraindicated during breast-feeding.

Dosing and Administration
Duration of treatment and dosage regimen is what is anavar established individually and depends on the process of localization and severity of the disease.

Adults:
The usual dose: 250 mg (1 tablet) 1 every day.

Onychomycosis: The duration of therapy of about 6-12 weeks. With the defeat of nails of fingers and feet (with the exception of the big toe), or the young age of the patient treatment duration may be less than 12 weeks. When infection of the big toe is usually sufficient 3-month course of treatment. In rare cases, the slow nail growth rate may require a longer period of treatment – up to 6 months or more.

Fungal infections of the skin: The duration of treatment with interdigital, plantar or “sock” type of localization of infection is 2-6 weeks, with mycoses of other parts of the body:. Shins – 2-4 weeks, the body – 4 week .;. in mycosis caused by Candida – 2-4 weeks .; with mycosis of the head caused by Microsporum canis – more than 4 weeks.

Children: usually prescribe 125 mg.

The duration of treatment of fungal infections of the scalp for about 4 weeks after infection Microsporum canis – maybe longer.
When a body weight less than 20 kg – 62.5 mg 1 time per day.
With a body weight from 20 kg to 40 kg – 125 mg 1 time per day.
When the body weight over 40 kg – 250 mg 1 time per day.

Elderly patients with drug administered in the same dose as adults. When expressed human liver and / or renal impairment (creatinine clearance <50 mL / min or serum creatinine what is anavar concentration in the blood of more than 300 mmol / L): 125 mg 1 time per day.

Side effects:
dyspeptic disorders (loss of appetite, nausea, diarrhea, feeling of fullness, abdominal pain); allergic skin reactions (rash, hives); musculoskeletal reactions (arthralgia, myalgia).

Taste disturbance, including their loss (recovery occurs within a few weeks after cessation of treatment).

Very rare: hepatotoxicity (increased activity of “liver” transaminases, hepatic failure), hepatobiliary disorders (cholestatic jaundice), malignant exudative erythema what is anavar, toxic epidermal necrolysis (Lyell’s syndrome), anaphylactoid reactions, agranulocytosis or thrombocytopenia, neutropenia .