Symptoms: nausea, vomiting, pain in the lower abdomen in the epigastric region. Treatment: gastric lavage, followed by the appointment of activated carbon and / or symptomatic therapy.
Interaction with other drugs
inhibits isoenzyme liquid anavar and inhibits the metabolism of drugs such as tricyclic antidepressants and selective serotonin uptake blockers (napr. desipramine, fluvoxamine) of b1-blockers (metoprolol, propranolol), antiarrhythmics (flecainide, propafenone), (eg., selegiline) antipsychotic and (eg., chlorpromazine, haloperidol).
Medications Inductors enzymes (eg. Rifampicin) can accelerate the excretion of terbinafine from the body. Medications inhibitors (eg. Cimetidine) may slow the metabolism and excretion of terbinafine from the body. With the simultaneous use of these drugs may require dose adjustment of terbinafine.
Possible disruption of the menstrual cycle, while the reception of terbinafine and oral contraceptives. It reduces the clearance of caffeine by 21% and prolongs its half-life by 31%. It does not affect the clearance of phenazone, digoxin, warfarin. Ethanol and other hepatotoxic drugs increase the risk of hepatotoxic effects.
Irregular use of terbinafine or premature discontinuation of treatment may lead to recurrence of the disease. On the duration of therapy can influence factors such as the presence of comorbidities, the state of the nails in the beginning of treatment. If after 2 weeks of treatment of skin infection is not marked improvement, it is necessary to re-determine the causative agent and its sensitivity to the drug.
Systemic application in onychomycosis is justified liquid anavar only in case of total destruction of the majority of the nails, the presence of pronounced subungual hyperkeratosis, ineffectiveness of previous local therapy.In the treatment of onychomycosis clinical response is usually seen after a few months after mycological cure and treatment discontinuation rate due to the rate of regrowth of healthy nail. Removal of the nail plate in the treatment of onychomycosis of brushes for 3 weeks. and onychomycosis stop for 6 weeks. not required.
If you have severe renal insufficiency (creatinine clearance less than 50 ml / min or creatinine in the blood of more than 300 mmol / l), with abnormal liver function the dose of terbinafine should be halved. If you have liver disease clearance of terbinafine can be reduced. With reduced liver function is assigned half of the adult dose. During treatment is necessary to control the level of liver transaminases in the serum.
In rare cases, after 3 months of treatment there is cholestasis and hepatitis. When liver function disorders symptoms (fatigue, persistent nausea, loss of appetite, abdominal pain, jaundice, dark urine or stool, colorless) the drug should be discontinued.
Appointment of terbinafine patients with psoriasis requires more diligence, because In very rare cases, terbinafine may trigger psoriasis flare. In the treatment of terbinafine should comply with the general rules of hygiene to prevent the possibility of re-infection through underwear and shoes. During the treatment liquid anavar. And at the end of treatment needed to produce the antifungal treatment of shoes, socks and stockings.