Combined medication. Codeine – antitussive central action; alkaloid phenanthrene series. Opioid receptor agonist, reduces the excitability of the cough center. At the recommended therapeutic doses does not cause depression of the respiratory center does not interfere with the function of ciliated epithelium and does buy anavar not diminish the bronchial secretion, enhances the effect of analgesic, hypnotic and sedative drugs. Activation of opioid receptors in the intestine causes relaxation of smooth muscle, reduction of motility and spasm of sphincter.
Terpine enhances secretion of bronchial glands, has expectorant.
Sodium hydrogen shifts pH bronchial mucus in the alkaline side, reduces the viscosity of sputum, to a certain extent also stimulates the motor function of the ciliated epithelium and bronchioles.
Reduces the cough reflex and helps to eliminate mucus from the airway by coughing. Maximum effect occurs within 30-60 minutes after ingestion and lasts for 2-6 hours.
Indications for use of
“dry” cough of various etiologies in diseases of the lungs and respiratory tract infections (including pneumonia, bronchitis, emphysema) in adults and children older than 12 years.
Hypersensitivity to buy anavar the drug, respiratory failure, asthma, concomitant use of ethanol or narcotic analgesics, children’s age (12 years), pregnancy and lactation.
Dosage and administration
: Inside, 1 tablet 2-3 times a day. The maximum duration of treatment without consulting a doctor – 5 days.
Allergic reactions (pruritus, urticaria).
Nausea, vomiting, constipation, headache, drowsiness.
Prolonged uncontrolled use may develop according to codeine.
Symptoms: vomiting, somnolence, atonic bladder, worsening coordination of movements of the eyeballs with visual impairment, bradypnea, depression of the respiratory center, arrhythmia, bradycardia.Treatment: gastric lavage with activated carbon and potassium permanganate, the introduction of respiratory analeptikov, atropine and competitive physiological antagonist kodeina- naloxone.
The interaction with other drugs
Chloramphenicol inhibits codeine metabolism in the liver and thereby enhances its effect. With simultaneous application of drugs which depress the central nervous system may increase the sedative effect and inhibitory effect on the respiratory center. Codeine increases the effects of ethanol on psychomotor functions.
When using large doses of codeine in the buy anavar action of cardiac glycosides (digoxin, etc.) Can be enhanced, as due to the weakening of peristalsis enhanced their absorption. Adsorbents, binders and overlying agents may reduce the absorption of codeine.
Patients with impaired renal function excretion of codeine slowed down, so it is recommended to extend the intervals between doses of the drug.
Because of the possibility of sedation during treatment is not recommended to engage in activities that require attention, speed of mental and motor responses.
During ingestion You can not drink alcohol. Athletes should be aware that the drug contains codeine and is doping.
Tablets. 10 tablets in blisters. 1 package with buy anavar the instruction on the medical application in a pack made of cardboard.
Distilled water, glycerol, urea , glyceryl stearate, avocado oil , isopropyl palmitate, cetylstearyl alcohol, octyldodecanol, detsilenglikol, acrylamide / sodium akriloildimetiltaurat copolymer, isohexadecane, polysorbate 80, phenoxyethanol, methylparaben, ethylparaben, butylparaben, isobutylparaben, propylparaben, cyclopentasiloxane and dimethiconol. guarana extract, essential oil of rosemary, pepper extract, horse chestnut extract, leaf extract of red grapes , of anavar cycle, nicotinic acid ( vitamin PP ).
Laminant tube of 75 ml in a carton box.
The mechanism of action
Warming effect: by improving the blood flow in the legs
Decongestants effect: by strengthening anavar cycle the walls of blood vessels
Skin Care Foot
power plate body tempo caen tarif body sculpt
Elderly patients with drug anavar administered in the same dose as adults.
When expressed violations of the liver and / or kidney creatinine clearance <50 mL / min or serum creatinine concentration in the blood of more than 300 mmol / L): 125 mg 1 time per day.
Dyspeptic disorders (loss of appetite, nausea, diarrhea, feeling of fullness, abdominal pain); allergic skin reactions (rash, hives); musculoskeletal reactions (arthralgia, myalgia), worsening of current systemic lupus erythematosus.
Taste disturbance, including their loss (recovery occurs within a few weeks after cessation of treatment).
Very rarely: hepatobiliary disorders (cholestatic jaundice), malignant exudative erythema (Stevens – Johnson), toxic epidermal necrolysis (Lyell’s syndrome), anaphylactoid reactions, agranulocytosis or thrombocytopenia, neutropenia, lymphopenia.
Symptoms: nausea, vomiting, anavar pain in the lower abdomen in the epigastric region.
Treatment: gastric lavage, followed by the appointment of activated carbon and / or symptomatic therapy.
Interaction with other drugs.
It inhibits CYP2D6 isoenzyme and inhibits the metabolism of drugs such as tricyclic antidepressants and selective serotonin uptake blockers (eg. Desipramine, fluvoxamine), β1-blockers (metoprolol, propranolol), antiarrhythmics (flecainide, propafenone), MAO- The inhibitor (selegiline) and antipsychotics (e.g., chlorpromazine, haloperidol).
Medications – inducers of enzymes (. Eg rifampicin) may accelerate the excretion of terbinafine from the body.
Medications – anavar inhibitors (. Eg cimetidine) may slow the metabolism and excretion of terbinafine from the body. With the simultaneous use of these drugs may require dose adjustment of terbinafine.
Possible disruption of the menstrual cycle while taking terbinafine and oral contraceptives.
It reduces the clearance of caffeine by 21% and prolongs its half-life by 31%. It does not affect the clearance of phenazone, digoxin, warfarin.
When combined with ethanol or drugs having hepatotoxic effect, there is a risk of liver disease drug.
Irregular use or premature discontinuation of terbinafine treatment lead to relapse.
On the duration of therapy can influence factors such as the presence of comorbidities, the state of the nails in the beginning of treatment.
If after 2 weeks of treatment, no improvement in the state, it is necessary to re-determine the causative agent and its sensitivity to the drug.
Systemic application in onychomycosis is anavar justified only in case of total destruction of the majority of the nails, the presence of pronounced subungual hyperkeratosis, ineffectiveness of previous local therapy.
In the treatment of onychomycosis clinical response is usually seen after a few months after mycological cure and treatment discontinuation rate due to the rate of regrowth of healthy nail. Removal of the nail plate in the treatment of onychomycosis of brushes for 3 weeks and onychomycosis stop for 6 weeks is required.
If you have severe renal insufficiency (creatinine clearance less than 50 ml / min or creatinine in the blood of more than 300 mmol / l), with abnormal liver function the dose of terbinafine should be halved.
In the presence of liver disease may be the clearance of terbinafine is reduced.
With reduced liver function is assigned half of the adult dose. During treatment is necessary to control the level of liver transaminases in the serum. In rare cases, after 3 months of treatment there is cholestasis and hepatitis. When liver function disorders symptoms (fatigue, persistent nausea, loss of appetite, abdominal pain, jaundice, dark urine or stool, colorless) the drug should be discontinued.
Appointment of terbinafine patients with psoriasis requires more diligence, because In very rare cases, terbinafine may trigger psoriasis flare.
In the treatment of terbinafine should comply with the general rules of hygiene to prevent the possibility of re-infection through underwear and shoes. During the treatment (2 weeks.) And finally antifungal treatment is necessary to produce shoes, socks and stockings. Effects on ability to drive and working mechanisms: terbinafine does not affect anavar the ability to drive and perform work requiring high concentration.
Terbinafine breaks early stage of the biosynthesis of the main component of the fungal cell membrane ergosterol by inhibiting the enzyme squalene epoxidase.
If oral administration is not effective in the treatment of multi-colored lichen, caused by Malassezia furfur.
Pharmacokinetics after oral administration is well absorbed through the 0.8 hour half the dose absorbed; after 4.6 hours of half the dose is distributed in the body.After 1-2 hours after oral administration of a single 250 mg dose of the maximum concentration of drug in blood plasma reaches 0.97 g / ml. Bioavailability anavar reviews is 80%.Food intake has no effect on the bioavailability of terbinafine.
Terbinafine extensively bound to plasma proteins (99%), is spreading rapidly in the tissue, penetrates the dermal layer of the skin and the nail plate. It penetrates into the secret of the sebaceous glands and accumulates in high concentrations in hair follicles, hair, skin and subcutaneous tissue.
. The half-life time of 16-18 hours, half-life of terminal phase -200-400 h Biotransformiroetsa in the liver to inactive metabolites; 80% of the dose excreted in urine as metabolites, the remainder (22%) – with the feces. Do not cumulated in the body. Age of the patients did not affect the pharmacokinetics of terbinafine, however, elimination may be reduced in patients with lesions of the kidneys and liver, resulting in high concentrations of terbinafine in the blood. Provided with breast milk.
Fungal infections of the scalp (trihofitia, mikrosporiya).
Skin and nail fungal infections caused anavar reviews (T. rubrum, mentagrophytes, verrucosum , violaceum), Microsporum (M. canis, M.gypseum) and floccosum.
Heavy, common ringworm smooth skin of the trunk and limbs requiring systemic treatment.
candidiasis skin and mucous membranes.
Hypersensitivity to any component of the drug; Children under 3 years of age and weighing up to 20 kg (for a given dosage form) during lactation.
Precautions: hepatic and / or renal failure, alcoholism, depression of bone marrow hematopoiesis, tumors, metabolic diseases, limb occlusive vascular disease.
Pregnancy and lactation: reception terbinafine during pregnancy is contraindicated because of the lack of sufficient information about its safety during pregnancy. Terbinafine is excreted in breast milk, so his appointment is contraindicated during breast-feeding.
Dosage and administration.
The duration of treatment and dosage regimen is established individually and depends on the process of localization and severity of the disease. Adults:
The usual dose: 250 mg (1 tablet) 1 every day.
Onychomycosis: duration of therapy of about 6-12 weeks. With anavar reviews the defeat of nails of fingers and feet (with the exception of the big toe), or the young age of the patient treatment duration may be less than 12 weeks. When infection of the big toe is usually sufficient 3-month course of treatment. In rare cases, the slow growth rate of the nail may need longer treatment to 6 months or more.
Fungal infections of the skin: the duration of treatment with interdigital, plantar or type “socks” localization of infection is 2-6 weeks, with mycoses of other parts of the body:. Shins – 2-4 weeks, the body – 4 week .;. when mycoses caused by Candida, 2-4 weeks .; with mycosis of the head caused by Microsporum canis – more than 4 weeks.
Children: usually prescribed 125 mg (1/2 tablet). The duration of treatment of fungal infections of the scalp for about 4 weeks after infection Microsporum canis – maybe longer. Weighing between 20 and 40 kg-125 mg 1 time per day. Weighing more than 40 kg -250 mg 1 time per day.
Was generally well tolerated. Side effects are usually mild or moderately expressed and are transient in nature. Below are the adverse events observed in clinical trials or post-market drug.
In evaluating the frequency of occurrence of side effects following the graduation used “very often”including isolated posts. On the part of the system hematopoiesis: rarely – neutropenia, agranulocytosis, thrombocytopenia, increased activity of “liver” transaminases, lymphopenia.immune system: very rare – anaphylactoid reactions (including angioedema), cutaneous and systemic lupus erythematosus. From the nervous system: often – headache pain; sometimes – a violation of taste sensations, including their loss (typically recovery occurs within a few weeks after cessation of treatment). There are some reports of cases of prolonged taste disturbance. In some cases in patients receiving the drug showed a decrease in food intake, which resulted in a significant reduction in weight. Liver: rare – hepatobiliary dysfunction (primarily cholestatic nature), including very rare cases of serious liver failure (some with a fatal outcome or requiring liver transplantation .) On the part of the gastrointestinal tract anavar dosage: very often – a sense of fullness, loss of appetite, indigestion, nausea. Weakly expressed abdominal pain, diarrhea. With the skin side and subcutaneous tissue: very often – not severe skin reactions (rash, urticaria), rarely – severe skin reactions (including Stevens-Johnson syndrome, toxic epidermal necrolysis); psoriasiform rash or exacerbation of psoriasis. Very rarely, there have been cases of hair loss, although a causal link with the administration of the drug has not been established.If by progressive skin rashes, treatment Terbifinom ® should be discontinued. On the part of the musculoskeletal system: very often – arthralgia, myalgia. Other : very rarely – fatigue.
There have been reports of a few cases of overdose (adopted dose amounted to 5 g), in which the observed headache, nausea, epigastric pain and dizziness.
Recommended in case of overdose, treatment involves action on the removal of the drug, primarily by the appointment of activated carbon and gastric lavage; if necessary, symptomatic and supportive therapy.
Interaction with other drugs The influence of other drugs on terbinafine The plasma clearance of terbinafine may be accelerated under the influence of drugs – inducers of metabolism and suppressed under the influence of inhibitors of cytochrome P450. If necessary, the simultaneous application of the above drugs and anavar dosage may require a corresponding correction of the last dosing regimen. Cimetidine may increase the effects of terbinafine or increase its concentration in plasma. Cimetidine reduces the clearance of terbinafine by 33%. Rifampicin may impair the action of terbinafine or reduce its concentration in plasma. Rifampicin increases terbinafine clearance by 100%. The effect of terbinafine on other drugs Studies conducted in vitro and in healthy volunteers show that terbinafine has little capacity to inhibit or enhance the clearance of most drugs that are metabolized by the participation of cytochrome (eg terfenadine, triazolam, tolbutamide or oral contraceptives), except for those that are metabolized with the participation o. Terbinafine does not influence the clearance of antipyrine or digoxin. There are reports of several cases of menstrual disorders in patients treated together with oral contraceptives, although the incidence these disorders are not higher than the average rate of such disorders in patients taking only oral contraceptives. Terbinafine may increase the effects of caffeine or increase its concentration in plasma. Terbinafine caffeine clearance decreases by 20%. In studies in vivo and in vitro have shown that terbinafine inhibits metabolism mediated by the enzymeanavar dosage.
These data may be clinically important for those drugs that are metabolized primarily by the enzyme: tricyclic antidepressants, beta adrenoblokatory. Selective serotonin reuptake inhibitors, antiarrhythmic drugs class 1C and monoamine oxidase inhibitors type B, -. In the case, if the drug is used at the same time has a small range of therapeutic concentrations of Terbinafine decreases the clearance of desipramine by 82%. The ethanol and other hepatotoxic drugs increase the risk of hepatotoxicity. terbinafine may weaken the effect of cyclosporine, and reduce its concentration in plasma.Terbinafine increases the clearance of cyclosporine by 15%.
has been shown that terbinafine inhibits metabolism mediated by the enzyme anavar dosage. It is therefore necessary to carry out continuous monitoring of patients receiving simultaneously with Terbifinom treatment with drugs predominantly metabolized with the participation of the enzyme (such as tricyclic antidepressants, betaadrenoblokatory, selective serotonin reuptake inhibitors, antiarrhythmic drugs class 1C and monoamine oxidase inhibitors type B), if applicable the drug has a small range of therapeutic concentrations at the same time.
Irregular use or premature ending of treatment increases the risk of relapse. If after 2 weeks of treatment, no improvement in the state, it is necessary to re-determine the causative agent and its sensitivity to the drug.
Before and during treatment requires monitoring of liver function.
The treatment must comply with the general rules of hygiene for the prevention of reinfection (via / underwear, footwear ).