Terbinafine breaks early stage of the biosynthesis of the main component of the fungal cell membrane ergosterol by inhibiting the enzyme squalene epoxidase.
If oral administration is not effective in the treatment of multi-colored lichen, caused by Malassezia furfur.
Pharmacokinetics after oral administration is well absorbed through the 0.8 hour half the dose absorbed; after 4.6 hours of half the dose is distributed in the body.After 1-2 hours after oral administration of a single 250 mg dose of the maximum concentration of drug in blood plasma reaches 0.97 g / ml. Bioavailability anavar reviews is 80%.Food intake has no effect on the bioavailability of terbinafine.
Terbinafine extensively bound to plasma proteins (99%), is spreading rapidly in the tissue, penetrates the dermal layer of the skin and the nail plate. It penetrates into the secret of the sebaceous glands and accumulates in high concentrations in hair follicles, hair, skin and subcutaneous tissue.
. The half-life time of 16-18 hours, half-life of terminal phase -200-400 h Biotransformiroetsa in the liver to inactive metabolites; 80% of the dose excreted in urine as metabolites, the remainder (22%) – with the feces. Do not cumulated in the body. Age of the patients did not affect the pharmacokinetics of terbinafine, however, elimination may be reduced in patients with lesions of the kidneys and liver, resulting in high concentrations of terbinafine in the blood. Provided with breast milk.
Fungal infections of the scalp (trihofitia, mikrosporiya).
Skin and nail fungal infections caused anavar reviews (T. rubrum, mentagrophytes, verrucosum , violaceum), Microsporum (M. canis, M.gypseum) and floccosum.
Heavy, common ringworm smooth skin of the trunk and limbs requiring systemic treatment.
candidiasis skin and mucous membranes.
Hypersensitivity to any component of the drug; Children under 3 years of age and weighing up to 20 kg (for a given dosage form) during lactation.
Precautions: hepatic and / or renal failure, alcoholism, depression of bone marrow hematopoiesis, tumors, metabolic diseases, limb occlusive vascular disease.
Pregnancy and lactation: reception terbinafine during pregnancy is contraindicated because of the lack of sufficient information about its safety during pregnancy. Terbinafine is excreted in breast milk, so his appointment is contraindicated during breast-feeding.
Dosage and administration.
The duration of treatment and dosage regimen is established individually and depends on the process of localization and severity of the disease. Adults:
The usual dose: 250 mg (1 tablet) 1 every day.
Onychomycosis: duration of therapy of about 6-12 weeks. With anavar reviews the defeat of nails of fingers and feet (with the exception of the big toe), or the young age of the patient treatment duration may be less than 12 weeks. When infection of the big toe is usually sufficient 3-month course of treatment. In rare cases, the slow growth rate of the nail may need longer treatment to 6 months or more.
Fungal infections of the skin: the duration of treatment with interdigital, plantar or type “socks” localization of infection is 2-6 weeks, with mycoses of other parts of the body:. Shins – 2-4 weeks, the body – 4 week .;. when mycoses caused by Candida, 2-4 weeks .; with mycosis of the head caused by Microsporum canis – more than 4 weeks.
Children: usually prescribed 125 mg (1/2 tablet). The duration of treatment of fungal infections of the scalp for about 4 weeks after infection Microsporum canis – maybe longer. Weighing between 20 and 40 kg-125 mg 1 time per day. Weighing more than 40 kg -250 mg 1 time per day.