Adverse events reported below are listed according to the classification systems of organs and frequency of occurrence. The frequency of occurrence was determined based on the following criteria: very often frequency unknown (insufficient data are available to assess). data from clinical studiesthree studies tetrakis drug simultaneously with the vaccine anavar results (mixed in the same syringe or administered separately) were vaccinated more than 2800 infants. After primary immunization, more than 8400 doses of vaccine most frequently recorded adverse reaction such as irritation (20.2%), and such local reactions at the injection site as redness> ) and induration> 2 cm (12 %).
These symptoms usually appear within 48 hours after vaccination and can last up to 48-72 hours. They were spontaneously and did not require any special treatment. After the primary immunization, there was a trend towards higher incidence of injection site reactions in the appointment revaktsiiiruyuschey dose. The safety profile drug tetrakis drug is not significantly different in different age groups, but some adverse events such as myalgia, malaise, and headache, are specific to children aged> 2 years of age and older. Violations of the metabolism and nutrition Very common: appetite disorders from the psyche Very common: irritability, unusual crying Common: sleep disorders uncommon: long lament of the nervous system Very common: insomnia, headache gastro-intestinal tract Very common:vomiting Common: diarrhea, the part of the musculoskeletal system and connective tissue Very common: myalgia General disorders and administration together Very common: redness at the injection site, soreness and swelling at the injection site, fever (≥38 ° C), malaise Common: induration at the injection site.
Uncommon: redness and swelling anavar results . during clinical vaccine studies tetrakis hypotonic-hyporesponsiveness episodes are not registered, but have been reported with the use of other vaccines against whooping cough reactions in the form of swelling, damaging one or both lower limbs may occur following immunization with vaccines containing component of Haemophilus influenzae type b. If a reaction occurs, it usually occurs during the primary immunization course and manifested during the first few hours after administration of the vaccine. At the same time there may be cyanosis, redness, transient purpura and in the reaction and a strong cry. All these symptoms disappear spontaneously with no sequelae for 24 hours. A case of this reaction was registered during clinical studies tetrakis vaccine administered simultaneously with a conjugate vaccine against infection by Haemophilus influenzae type b, in various areas of the body. When assigning vaccine tetrakis children aged 5-12 years later as a booster dose response tetrakis vaccine in children at this age group is rarely observed (as compared to the anavar results vaccine with pertussis tselnoklechnochnym administered at the same age), or with the same frequency (in compared with vaccine, administered at the same age).