Low toxic soluble forms complex compounds with heavy metals and rare earth (lead, mercury, iron, zinc, copper, manganese, vanadium, chromium, uranium, yttrium, cesium, etc.) By replacing metal ions of calcium, more stable than the calcium; It helps to eliminate them from the body through the urinary tract. The drug does not generate communication with barium ions, strontium, et al., The stability constant which is less than that of calcium. When anavar pills administered intravenously, and urinary excretion of lead chelates starts after 1 hour after administration, the excretion peak occurs within 24 – 48 hours.
After intravenous administration of the drug is uniformly distributed in the extracellular fluid. plasma half-life period is 20 minutes. Return with urine in the form of chelates and unaltered.
Indications for use:
Acute and chronic poisoning by lead, cobalt, cadmium, uranium, cesium, yttrium, mercury, thorium, et al., Including the treatment of lead colic syndrome.
- individual hypersensitivity to the drug;
- nephritis, nephrosis, renal failure;
- cirrhosis, acute and chronic hepatitis with severe liver failure;
- pregnancy, lactation.
Dosage and administration:
Intravenously 10-20 ml of a 10% solution anavar pills of 250-500 ml of isotonic sodium chloride solution or 5% dextrose solution. . The duration of the introduction at least one hour
single and daily doses for intravenous administration are, respectively, 2 g (20 ml of a 10% solution) and 4 g
The drug is administered daily for 3 – 4 days, followed by a break for 3-4 days. When administered twice a day interval between infusions is at least 3 hours. The course of treatment 1 month.
Headache, myalgia, nausea, vomiting, ringing in the ears, encephalopathy (in children), tremor, anorexia, edema of the nasal mucosa, lacrimation, anemia, dermatitis.
From the urinary system: acute necrosis of the proximal tubule damage to the distal tubules and the renal glomerulus .
cardio-vascular system: decrease in blood pressure, arrhythmia.
from the musculoskeletal system: arthralgia.
Laboratory findings:. glucosuria, proteinuria, microscopic hematuria, reduction of Zn2 + in the blood
at the beginning of treatment in some patients lead intoxication appears slight aggravation, which is manifested deterioration of general well-being, increased pain in the limbs, loss of appetite.
Rarely – decrease in hemoglobin concentration, the anavar pills increase in the number of reticulocytes; short-term reduction in the total level of iron in the blood and plasma, which quickly recovered after discontinuation of the drug. In some cases, there is reduction of vitamin B12 in the blood.
Other: fever, chills, malaise, weakness, sneezing, thirst.
Symptoms:. Increased severity of side-effects, cerebral edema, renal tubular necrosis
introduction of large doses of calcium-Tetatsin (50-60 g) can lead to toxic nephrosis.
Treatment: osmodiuretiki (mannitol), forced diuresis, maintenance of vital functions .
Interaction with other drugs
Concomitant use Tetatsin-calcium-zinc insulin preparations of iron, reduces the effectiveness of the latter.
In acute nutritional metal poisoning introduction Tetatsin calcium is made after a thorough cleansing of the gastrointestinal tract (gastric lavage, siphon enema).
Complexes with metals readily soluble and metals may again reabsorbed in the stomach and intestines, increasing the symptoms and severity of poisoning.
In the treatment of Tetatsin-calcium it is advisable to take iron supplements (oral) and cyanocobalamin (5-6 injections of 100 mg every other day).
to reduce the risk of side effects is recommended prior to treatment to ensure adequate urine output and maintain it during treatment.
it is necessary to warn the patient of the need to inform anavar pills the doctor in case of delay urinary excretion over 12 hours. When oliguria, increasing the amount of epithelial cells in the urine, increasing the severity of proteinuria and haematuria requires removal of the drug. ECG monitoring is required.