Combined preparation, has analgesic and antipyretic effect. Anavar steroidl anti-inflammatory drug, has analgesic, antispasmodic effect on the smooth muscles of the urinary and biliary tract. Caffeine has a tonic effect (reduces sleepiness and fatigue, enhances mental and physical performance, increases heart rate, increases blood pressure in patients with arterial hypotension). Codeine has an analgesic effect and improves the portability of pain;phenobarbital – sedative and antispasmodic action.
Pain syndrome of different origin: headache, toothache, pain in muscles and joints, neuralgia, painful menstruation, with radiculitis.
Can also be used to reduce elevated body temperature and alleviate the symptoms of malaise at the “colds” and other infectious and inflammatory diseases.
Hypersensitivity to the drug and other derivatives pyrazolone (phenylbutazone). Expressed human liver and kidneys; gastric ulcer and duodenal ulcer (in the acute stage); bronchospasm; State, accompanied by respiratory depression, blood disorders (leukopenia, hemolytic anemia); increased intracranial pressure, head injury; acute myocardial infarction; cardiac arrhythmias; high blood pressure; deficiency of glucose-6-phosphate dehydrogenase; alcohol intoxication; pregnancy and lactation; children’s age (14 years).
used in patients with impaired renal or hepatic anavar steroid function, with gastric ulcer and duodenal ulcer in remission, the elderly.
Dosing and Administration
Inside, 1 tablet 1-4 times a day, with some liquid. The maximum daily dose – 4 tablets.
Allergic reactions (rash, pruritus, urticaria), dizziness, drowsiness, decreased speed of psychomotor reactions, leukopenia, granulocytopenia, agranulocytosis, palpitations, nausea and vomiting, constipation.About all the side effects of the drug, including those not mentioned in this leaflet should be reported to your doctor.
Prolonged uncontrolled administration of high doses may: violation anavar steroid of liver and kidney function; addictive (weakening of the analgesic effect); drug dependence (codeine). Symptoms: nausea, vomiting, stomach pain, palpitations, respiratory depression. It is necessary to immediately seek medical help. Treatment: Induce vomiting, stomach wash water, take activated carbon and carry out symptomatic treatment.
These post-marketing surveillance
Because spontaneous reports the following adverse events during the commercial use of the drug recorded very rare from a population with an indefinite number of vaccinated this vaccine, their frequency was classified as “frequency not known”. Violations of the blood and lymphatic system lymphadenopathy Immune system Anaphylactic anavar for sale reactions such as face edema, angioedema nervous systemConvulsions on higher or without fever Syncope skin and subcutaneous tissue disorders allergic like symptoms, such as various types of rash, erythema, urticaria General disorders and with the introduction of Severe edema ( ≥5 cm) at the injection site, including swelling, extends beyond one or both of the adjacent joints. These reactions appear 24-72 hours after administration of the vaccine, and can be accompanied by redness, an increase in temperature of the skin at the injection site, sensitivity or tenderness at the injection site. These symptoms disappeared spontaneously within 3-5 days without any additional treatment. It is assumed that the probability of such reactions is increased depending on the number of previous administrations of the vaccine with acellular pertussis component. This probability is higher after administration of the 4th and 5th dose of such a vaccine.
Potential adverse events
The Company has evidence that after the introduction of other vaccines containing tetanus toxoid, observed neuritis of the brachial nerve, and Guillain-Barre syndrome.
Data not available.
Interaction with other drugs
Except for immunosuppressive therapy (see. “Special Instructions” section) there is no reliable data on the possible mutual influence when used with other medicines, including other vaccines.
The vaccine tetrakis can be administered in the same syringe with conjugate vaccine against infection caused by Haemophilus influenzae type anavar for sale is diluted directly tetrakis vaccine), or simultaneously with the vaccine (in different parts of the body).
The vaccine tetrakis can be administered concomitantly with measles-mumps-rubella, varicella, hepatitis B, in different parts of the body.
The doctor should be informed about any recent coincides with the vaccination using a child any other medicines .
The doctor should be informed about all the cases of adverse reactions, including those not listed in these instructions. Before each vaccination, to prevent possible allergic and other reactions, the doctor must clarify the state of health, immunization history, medical history of the patient and the immediate family members (in particular – allergic), cases of adverse events leading up to the introduction of vaccines. The doctor must have medicines, and tools needed in the development of hypersensitivity reactions.
Immunosuppressive therapy, or immune deficiency condition may be the cause of a weak immune response to the vaccine. In these cases it is recommended to postpone vaccination until anavar for sale the end of such treatment or remission. However, persons with chronic immunodeficiency (e.g., HIV) vaccination is recommended even if the immune response may be diminished.
When the development history of Guillain-Barre syndrome or brachial neuritis in response to any vaccine comprising a tetanus toxoid solution vaccination tetrakis drug should be carefully justified. Typically, in such cases justified is to complete primary immunization (if you enter at least 3 doses).
The potential risk of apnea and the need for respiratory monitoring for 48-72 h should be considered when conducting a primary immunization course in very preterm infants born at 28 weeks or less, particularly in having a history of respiratory signs of immaturity. Since the benefits of immunization of this group of children is high, vaccination should not be delayed or regarded as contraindicated.
Adverse events reported below are listed according to the classification systems of organs and frequency of occurrence. The frequency of occurrence was determined based on the following criteria: very often frequency unknown (insufficient data are available to assess). data from clinical studiesthree studies tetrakis drug simultaneously with the vaccine anavar results (mixed in the same syringe or administered separately) were vaccinated more than 2800 infants. After primary immunization, more than 8400 doses of vaccine most frequently recorded adverse reaction such as irritation (20.2%), and such local reactions at the injection site as redness> ) and induration> 2 cm (12 %).
These symptoms usually appear within 48 hours after vaccination and can last up to 48-72 hours. They were spontaneously and did not require any special treatment. After the primary immunization, there was a trend towards higher incidence of injection site reactions in the appointment revaktsiiiruyuschey dose. The safety profile drug tetrakis drug is not significantly different in different age groups, but some adverse events such as myalgia, malaise, and headache, are specific to children aged> 2 years of age and older. Violations of the metabolism and nutrition Very common: appetite disorders from the psyche Very common: irritability, unusual crying Common: sleep disorders uncommon: long lament of the nervous system Very common: insomnia, headache gastro-intestinal tract Very common:vomiting Common: diarrhea, the part of the musculoskeletal system and connective tissue Very common: myalgia General disorders and administration together Very common: redness at the injection site, soreness and swelling at the injection site, fever (≥38 ° C), malaise Common: induration at the injection site.
Uncommon: redness and swelling anavar results . during clinical vaccine studies tetrakis hypotonic-hyporesponsiveness episodes are not registered, but have been reported with the use of other vaccines against whooping cough reactions in the form of swelling, damaging one or both lower limbs may occur following immunization with vaccines containing component of Haemophilus influenzae type b. If a reaction occurs, it usually occurs during the primary immunization course and manifested during the first few hours after administration of the vaccine. At the same time there may be cyanosis, redness, transient purpura and in the reaction and a strong cry. All these symptoms disappear spontaneously with no sequelae for 24 hours. A case of this reaction was registered during clinical studies tetrakis vaccine administered simultaneously with a conjugate vaccine against infection by Haemophilus influenzae type b, in various areas of the body. When assigning vaccine tetrakis children aged 5-12 years later as a booster dose response tetrakis vaccine in children at this age group is rarely observed (as compared to the anavar results vaccine with pertussis tselnoklechnochnym administered at the same age), or with the same frequency (in compared with vaccine, administered at the same age).
The immune response after the booster studies immunogenicity conducted among children of the 2nd year of life, have received a primary vaccination course of three doses of tetrakis vaccine demonstrated a high level of immune responses to all components following the introduction of the 4th dose (booster dose). Studies carried out in children anavar cycle for women aged 12-24 months who received a primary immunization course is three doses of vaccine with whole cell pertussis component demonstrated that subsequent booster vaccine is safe and tetrakis immunogenic for all vaccine components.
The primary vaccination and revaccination of children, ranging from 3-mssyachnogo age against diphtheria, tetanus, pertussis, polio.
– Progressive encephalopathy, accompanied by convulsions or without.
– Encephalopathy of unknown etiology, which developed within 7 days after the administration of any vaccine (whole cell or acellular), containing antigen of Bordetella pertussis.
– Strong reaction, which developed within 48 h after the last immunization with a vaccine containing pertussis: a rise in body temperature to 40 ° C and above, a long unusual crying syndrome (lasting more than 3 hours), febrile and afebrile seizures, hypotonic-hyporesponsiveness syndrome.
– Giperchuvstvitelyyust after previous administration of any vaccine for the prevention of diphtheria, tetanus, pertussis, polio
– Hypersensitivity to any vaccine component, as well as glutaraldehyde, neomycin, streptomycin and polymyxin .
– diseases accompanied by fever, acute infectious or chronic disease in the acute stage. Vaccination is carried out 2-4 weeks after recovery, or in the period of convalescence, or remission. In non-severe acute respiratory viral infection, acute intestinal diseases and others. Vaccinations carried out immediately after the normalization of temperature.
– If there is a history of the child’s febrile anavar cycle for women convulsions not related to a previous vaccination, should monitor the body temperature of the graft within 48 hours after vaccination and, if it increase, regularly used antipyretic (fever-reducing) drugs during this period.
– When thrombocytopenia and other bleeding disorders the vaccine should be used with caution because of the risk of bleeding as a result of the injection.
Application of pregnancy and during breastfeeding
Because the vaccine Tstraksim used for vaccination of children, data on the effect of the drug on pregnancy and breast-feeding are absent.
Dosing and Administration
One dose of vaccine is 0.5 ml. The primary vaccination in accordance with the National calendar of preventive vaccination of the primary vaccination course consists of three doses of vaccine administered at an interval of 1.5 months:. At the age of 3, 4.5 and 6 months Revaccination According to the anavar cycle for womencalendar preventive vaccination revaccination is carried out once at the age of 18 months. If any of the following vaccination schedule intervals between the administration of the next dose of the vaccine are not changed, including the interval before the fourth (a booster) dose – 12 months. Further revaccination against polio carried out in the terms provided by the National calendar of preventive vaccinations. In all cases of violations of the vaccination schedule should be guided by the doctor’s instructions for use of the drug and the recommendations of the National Immunization Schedule.
The route of administration Just before administration shake until a homogeneous whitish turbid suspension. The vaccine is administered intramuscularly at a dose of 0.5 mL, the recommended injection site -. Middle third of the anterolateral thigh for children under the age of 24 months and deltoid shoulder muscle for older children . Do not inject intravenously or intradermally need to make before the introduction of the needle does not penetrate into a blood vessel.
Low toxic soluble forms complex compounds with heavy metals and rare earth (lead, mercury, iron, zinc, copper, manganese, vanadium, chromium, uranium, yttrium, cesium, etc.) By replacing metal ions of calcium, more stable than the calcium; It helps to eliminate them from the body through the urinary tract. The drug does not generate communication with barium ions, strontium, et al., The stability constant which is less than that of calcium. When anavar pills administered intravenously, and urinary excretion of lead chelates starts after 1 hour after administration, the excretion peak occurs within 24 – 48 hours.
After intravenous administration of the drug is uniformly distributed in the extracellular fluid. plasma half-life period is 20 minutes. Return with urine in the form of chelates and unaltered.
Indications for use:
Acute and chronic poisoning by lead, cobalt, cadmium, uranium, cesium, yttrium, mercury, thorium, et al., Including the treatment of lead colic syndrome.
- individual hypersensitivity to the drug;
- nephritis, nephrosis, renal failure;
- cirrhosis, acute and chronic hepatitis with severe liver failure;
- pregnancy, lactation.
Dosage and administration:
Intravenously 10-20 ml of a 10% solution anavar pills of 250-500 ml of isotonic sodium chloride solution or 5% dextrose solution. . The duration of the introduction at least one hour
single and daily doses for intravenous administration are, respectively, 2 g (20 ml of a 10% solution) and 4 g
The drug is administered daily for 3 – 4 days, followed by a break for 3-4 days. When administered twice a day interval between infusions is at least 3 hours. The course of treatment 1 month.
Headache, myalgia, nausea, vomiting, ringing in the ears, encephalopathy (in children), tremor, anorexia, edema of the nasal mucosa, lacrimation, anemia, dermatitis.
From the urinary system: acute necrosis of the proximal tubule damage to the distal tubules and the renal glomerulus .
cardio-vascular system: decrease in blood pressure, arrhythmia.
from the musculoskeletal system: arthralgia.
Laboratory findings:. glucosuria, proteinuria, microscopic hematuria, reduction of Zn2 + in the blood
at the beginning of treatment in some patients lead intoxication appears slight aggravation, which is manifested deterioration of general well-being, increased pain in the limbs, loss of appetite.
Rarely – decrease in hemoglobin concentration, the anavar pills increase in the number of reticulocytes; short-term reduction in the total level of iron in the blood and plasma, which quickly recovered after discontinuation of the drug. In some cases, there is reduction of vitamin B12 in the blood.
Other: fever, chills, malaise, weakness, sneezing, thirst.
Symptoms:. Increased severity of side-effects, cerebral edema, renal tubular necrosis
introduction of large doses of calcium-Tetatsin (50-60 g) can lead to toxic nephrosis.
Treatment: osmodiuretiki (mannitol), forced diuresis, maintenance of vital functions .
Interaction with other drugs
Concomitant use Tetatsin-calcium-zinc insulin preparations of iron, reduces the effectiveness of the latter.
In acute nutritional metal poisoning introduction Tetatsin calcium is made after a thorough cleansing of the gastrointestinal tract (gastric lavage, siphon enema).
Complexes with metals readily soluble and metals may again reabsorbed in the stomach and intestines, increasing the symptoms and severity of poisoning.
In the treatment of Tetatsin-calcium it is advisable to take iron supplements (oral) and cyanocobalamin (5-6 injections of 100 mg every other day).
to reduce the risk of side effects is recommended prior to treatment to ensure adequate urine output and maintain it during treatment.
it is necessary to warn the patient of the need to inform anavar pills the doctor in case of delay urinary excretion over 12 hours. When oliguria, increasing the amount of epithelial cells in the urine, increasing the severity of proteinuria and haematuria requires removal of the drug. ECG monitoring is required.